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Our Research

IMAGINE FMT

Fecal Microbiota Transplantation for Major Depressive disorder with Irritable Bowel Syndrome

  • The IMAGINE-FMT clinical trial evaluates the effectiveness of combining standard interventions with oral Fecal Microbiota Transplantation (FMT) in the treatment of Depression with or without Irritable Bowel Syndrome (IBS).

  • This study is an open-label controlled trial in which adults from in or around Calgary, Alberta who have a diagnosis of Major Depressive Disorder with or without IBS are assigned to additionally receive either FMT capsules or to continue with their current treatment. Clinical data, brain imaging data, stool, urine, and blood samples are collected to study the changes in depressive symptoms, microbial profile of the gut, and inflammatory markers.

  • The trial may lead to a better understanding and acceptability of alternative options that are more effective and tolerable for individuals with Major Depressive Disorder with comorbid Irritable Bowel Syndrome.

ORBIT (taylORed psychoBIoTics biobank)

A Microbiome Biobank for Mental Health Research dddddd

  • The biobank is designed to examine the bidirectional communication between the gut bacteria and the brain by collecting stool, urine, saliva, blood samples, and clinical data to study the microbes present in the gut. It is recruiting donors from around the province of Alberta who has confirmed diagnoses of:

    • Depression

    • Bipolar disorder

    • Obsessive-compulsive disorder

    • Post-traumatic stress disorder

    • Autism

    • Eating disorders, and

    • Panic disorder

  • The Taylored Psychobiotics Biobank is the largest of detailed mental illness and microbiome information in the world.

  • The study of the role of the gut microbiome and bacterial biomarkers may lead to a better understanding of these disorders and could revolutionize the treatment of mental illness with made at the University of Calgary solutions.

The FMT-TRD Trial

Fecal Microbiota Transplantation for Treatment Resistant Major Depressive disorder

  • The FMT-TRD clinical trial evaluates the effectiveness of combining standard mood stabilizers with oral Fecal Microbiota Transplantation (FMT) in the treatment of Treatment Resistant Depression.

  • This study is a randomized controlled trial in which participating adults from in and around Calgary, Alberta who have a diagnosis of Treatment Resistant Depression are assigned to receive either FMT capsules or placebo capsules. Clinical data and stool, urine, blood samples are collected to examine the changes in depressive symptoms, microbial profile of the gut, and inflammatory markers.

  • This trial may lead to a better understanding and acceptability of alternative options that are more effective and tolerable for individuals with Major Depressive Disorder.